石云
博士，海外優青，研究員
Email：shiyun@@gdiist.cn
個人簡介：
2007年博士畢業于佐治亞州立大學生物學系生理專業。2008-2012年在加州大學舊金山分校藥理系做博士后研究，師從Roger Nicoll院士。從2013年起相續任南京大學模式動物研究所教授和副所長，2022年任廣東省智能科學和技術研究院研究員和研究組長。入選海外高層次優秀青年人才計劃，江蘇省雙創人才計劃和江蘇省杰出青年。主要從事神經突觸傳遞和可塑性機制研究。主持國家自然科學基金委基金5項，主持和參加科技部課題3項。研究成果發表在Nature, Neuron, PNAS, Brain, Cell Discovery, Cell Reports, Nature Communications, Mol Psychiatry, eLife等雜志。
認知神經網絡與可塑性研究組：
本研究組圍繞中樞興奮性神經遞質系統，研究突觸傳遞和可塑性發生的基本機理。研究內容包括谷氨酸受體和輔助亞基的基本組成、空間結構、功能調控、合成和定位機制，從而理解興奮性突觸傳遞和可塑性發生的基本規律。課題組也以病人家系為著力點，建立動物模型研究突觸紊亂和神經認知疾病的關系。
研究組另一個研究方向圍繞機體內感覺系統的感知和神經網絡展開。機體內感覺系統，包括渴覺、飽饑覺、血壓感知、尿意等都是感知機械以及體內化學信號，并由特殊的神經網絡系統編解碼。研究組以往的研究發現TMEM63家族編碼了一類新型的機械和滲透壓敏感的離子通道，今后的研究將圍繞TMEM63家族通道的生理功能以及內感覺系統信號的編解碼展開。
代表論著：
1. Teng XY, Hu P, Zhang CM, Zhang QX, Yang G, Zang YY, Liu ZX, Chen G, Shi YS. (2024) OPALIN is an LGI1 receptor promoting oligodendrocyte differentiation. PNAS. 121(32):e2403652121.
2. Yang G, Jia M, Li G, Zang YY, Chen YY, Wang YY, Zhan SY, Peng SX, Wan G, Li W, Yang JJ, Shi YS. (2024) TMEM63B Channel Is the Osmosensor Required for Thirst Drive of Interoceptive Neurons. Cell Discovery, 10(1):1
3. Shi T, Shen S, Shi Y, Wang Q, Zhang G, Lin J, Chen J, Bai F, Zhang L, Wang Y, Gong W, Shao X, Chen G, Yan W, Chen X, Ma Y, Zheng L, Qin J, Lu K, Liu N, Xu Y, Shi YS, Jiang Q, Guo B (2024) Osteocyte-derived sclerostin impairs cognitive function during ageing and Alzheimer's disease progression. Nature Metabolism, Online ahead of print.
4. Rinaldi B, Bayat A, Zachariassen LG, Sun JH, Ge YH, Zhao D, Bonde K, Madsen LH, Awad IAA, Bagiran D, Sbeih A, Shah SM, El-Sayed S, Lyngby SM, Pedersen MG, Stenum-Berg C, Walker LC, Krey I, Delahaye-Duriez A, Emrick LT, Sully K, Murali CN, Burrage LC, Plaud Gonzalez JA, Parnes M, Friedman J, Isidor B, Lefranc J, Redon S, Heron D, Mignot C, Keren B, Fradin M, Dubourg C, Mercier S, Besnard T, Cogne B, Deb W, Rivier C, Milani D, Bedeschi MF, Di Napoli C, Grilli F, Marchisio P, Koudijs S, Veenma D, Argilli E, Lynch SA, Au PYB, Ayala Valenzuela FE, Brown C, Masser-Frye D, Jones M, Patron Romero L, Li WL, Thorpe E, Hecher L, Johannsen J, Denecke J, McNiven V, Szuto A, Wakeling E, Cruz V, Sency V, Wang H, Piard J, Kortüm F, Herget T, Bierhals T, Condell A, Zeev BB, Kaur S, Christodoulou J, Piton A, Zweier C, Kraus C, Micalizzi A, Trivisano M, Specchio N, Lesca G, M?ller RS, Tümer Z, Musgaard M, Gerard B, Lemke JR, Shi YS, Kristensen AS.(2023) Gain-of-function and loss-of-function variants in GRIA3 lead to distinct neurodevelopmental phenotypes. Brain, Online ahead of print.
5. Qin Y, Yu D, Wu D, Dong J, Li WT, Ye C, Cheung KC, Zhang Y, Xu Y, Wang Y, Shi YS, Dang S. (2023) Cryo-EM structure of TMEM63C suggests it functions as a monomer. Nature Communications, 14(1):7265.
6. Peng SX, Pei J, Rinaldi B, Chen Jiang, Ge YH, Jia M, Wang J, Delahaye-Duriez A, Sun J, Zang YY, Shi YY, Zhang N, Gao X, Milani D, Xu X, Sheng N, Gerard B, Chen Zhang C, Bayat A, Liu N, Yang JJ, Shi YS. (2022) Dysfunction of AMPA receptor GluA3 is associated with aggressive behavior in human. Mol Psychiatry, 27(10):4092-4102.
7. Li QQ, Chen J, Hu P, Jia M, Sun JH, Feng HY, Qiao FC, Zang YY, Shi YY, Chen G, Sheng N, Xu Y, Yang JJ, Xu Z, Shi YS. (2022) Enhancing GluN2A-type NMDA receptors impairs long-term synaptic plasticity and learning and memory. Mol Psychiatry, 27(8):3468-3478.
8. He L, Sun J, Gao Y, Li B, Wang Y, Dong Y, An W, Li H, Yang B, Ge Y, Zhang XC, Shi YS, Zhao Y. (2021) Kainate receptor modulation by Neto2. Nature, 599(7884):325-329.
9. Jiang CH, Wei M, Zhang C, Shi YS. (2021) The amino-terminal domain of GluA1 mediates LTP maintenance via interaction with neuroplastin-65. PNAS,118(9):e2019194118.
10. Du H, Ye C, Wu D, Zang YY, Zhang L, Chen C, He XY, Yang JJ, Hu P, Xu Z, Wan G, Shi SY. (2020) The cation channel TMEM63B is an osmosensor required for hearing. Cell Reports, 31:107596.
11. Duan GF, Xu S, Ye Y, Tao W, Nicoll RA,Shi YS, and Sheng N.(2018) Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain. Nature Communications, 9(1):4879.
12. Sheng N, Bemben MA, Díaz-Alonso J, Tao W, Shi YS, Nicoll RA. (2018) LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes. PNAS, 115(15):3948-3953.
13. Sheng N, Shi YS, Nicoll RA. (2017) The amino-terminal domains of kainate receptors determine the differential dependence on Neto auxiliary subunits for trafficking. PNAS, 114(5):1159-1164.
14. Niu Y, Dai Z, Liu W, Zhang C, Yang Y, Guo Z, Li X, Xu C, Huang X, Wang Y, Shi YS, Liu JJ. (2017) Ablation of SNX6 leads to defects in synaptic function of CA1 pyramidal neurons and spatial memory. eLife, 6. pii: e20991.
15. He XY, Li YJ, Kalyanaraman C, Qiu LL, Chen C, Xiao Q, Liu WX, Zhang W, Yang JJ, Chen G, Jacobson MP, Shi YS. (2016) GluA1 signal peptide determines the spatial assembly of heteromeric AMPA receptors. PNAS, 113(38):E5645-54.
16. Granger AJ, Shi Y, Lu W, Cerpas M, Nicoll RA. (2013) LTP requires an extrasynaptic pool of glutamate receptors independent of subunit type. Nature, 493(7433)，495-500
17. Herring B, Shi Y, Suh YH, Zheng CY, Schmid SM, Roche KW, Nicoll RA. (2013) Cornichon proteins determine the subunit composition of synaptic AMPA receptors. Neuron, 77(6),1083-96
18. Gray JA, Shi Y, Usui H, During MJ, Sakimura K, Nicoll RA. (2011) Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: analysis of single-cell GluN2 subunit deletion in vivo. Neuron, 71(6), 1085-1101
19. Shi Y, Suh YH, Milstein AD, Isozaki K, Schmid SM, Roche KW, Nicoll RA. (2010) Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating. PNAS, 107(37), 16315-16319
20. Shi Y, Lu W, Milstein AD, Nicoll RA. (2009) The stoichiometry of AMPA receptors and TARPs varies by neuronal cell types. Neuron, 62(5), 633-40
21. Lu W, Shi Y, Jackson A, Bjorgan K, During MJ, Sprengel R, Seeburg PH, Nicoll RA. (2009) Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach. Neuron, 62(2), 254-68
