時(shí)穎超研究員
博士，研究組組長(zhǎng)
Email: shiyingchao@@gdiist.cn
個(gè)人簡(jiǎn)介：
時(shí)穎超，研究員，神經(jīng)細(xì)胞圖譜與認(rèn)知網(wǎng)絡(luò)研究組組長(zhǎng)；2018年于中國(guó)科學(xué)院生物物理研究所獲理學(xué)博士學(xué)位。2018年9月至2022年10月，先后在中國(guó)科學(xué)院生物物理研究所擔(dān)任助理研究員、副研究員。 2022年11月起，擔(dān)任廣東省智能科學(xué)與技術(shù)研究院神經(jīng)細(xì)胞圖譜與認(rèn)知網(wǎng)絡(luò)研究組組長(zhǎng)、研究員。獲國(guó)家自然科學(xué)基金面上項(xiàng)目、廣東省杰出青年項(xiàng)目、科技創(chuàng)新2030“腦科學(xué)與類腦研究”重大項(xiàng)目和中國(guó)科學(xué)院青年創(chuàng)新促進(jìn)會(huì)人才項(xiàng)目等資助。時(shí)穎超研究員長(zhǎng)期致力于中間神經(jīng)元多樣性形成機(jī)制的研究，近三年研究成果以第一作者/共同通訊發(fā)表于Science、Cell Research、PLOS Biology和Current Opinion in Neurobiology等雜志。
神經(jīng)細(xì)胞圖譜與認(rèn)知網(wǎng)絡(luò)研究組：
大腦是哺乳動(dòng)物最復(fù)雜的器官，理解大腦的結(jié)構(gòu)與功能是最具挑戰(zhàn)性的前沿科學(xué)問(wèn)題，是理解認(rèn)知、思維、意識(shí)和語(yǔ)言（腦功能）的神經(jīng)基礎(chǔ)。復(fù)雜而精細(xì)的腦功能活動(dòng)的實(shí)現(xiàn)有賴于多樣的神經(jīng)細(xì)胞的協(xié)作及神經(jīng)網(wǎng)絡(luò)的建立。系統(tǒng)解析大腦中神經(jīng)細(xì)胞的類型、基因表達(dá)特征、神經(jīng)元放電模式及網(wǎng)絡(luò)連接模式等信息，對(duì)于繪制神經(jīng)細(xì)胞圖譜和解析認(rèn)知網(wǎng)絡(luò)至關(guān)重要。該研究方向?qū)τ诮沂灸X功能和腦疾病機(jī)制及治療靶點(diǎn)有重要意義。
本課題組應(yīng)用單細(xì)胞多組學(xué)技術(shù)，聯(lián)合分子和細(xì)胞生物學(xué)、電生理學(xué)、行為學(xué)等多種技術(shù)手段，繪制包含神經(jīng)細(xì)胞類型、分子特征及網(wǎng)絡(luò)連接模式等多維度信息的人和小鼠腦神經(jīng)細(xì)胞圖譜及認(rèn)知網(wǎng)絡(luò)。同時(shí)，本課題組還致力于三維類腦器官培養(yǎng)技術(shù)的創(chuàng)新及應(yīng)用，并以此為模型來(lái)探究神經(jīng)發(fā)生、神經(jīng)元遷移及神經(jīng)環(huán)路建立等過(guò)程的形成模式及腦疾病的發(fā)病機(jī)制，進(jìn)一步輔助神經(jīng)細(xì)胞圖譜及認(rèn)知網(wǎng)絡(luò)的繪制及解析。
代表性論著：
(1) Yingchao Shi*, Mengdi Wang*, Da Mi*, Tian Lu, Bosong Wang, Hao Dong, Suijuan Zhong, Youqiao Chen, Le Sun, Xin Zhou, Qiang Ma, Zeyuan Liu, Wei Wang, Junjing Zhang, Qian Wu, Oscar Marín, Xiaoqun Wang. Mouse and human share conserved transcriptional programs for interneuron development. Science, 2021, 374: eabj6641.（第一作者）
(2) Yingchao Shi*, Luwei Huang*, Hao Dong*, Meng Yang*, Wenyu Ding, Xiang Zhou, Tian Lu, Zeyuan Liu, Xin Zhou, Mengdi Wang, Bo Zeng, Yinuo Sun, Suijuan Zhong, Bosong Wang, Wei Wang, Chonghai Yin, Xiaoqun Wang, Qian Wu. Decoding the spatiotemporal regulation of transcription factors during human spinal cord development. Cell Research (2023) 0:1-21; https://doi.org/10.1038/s41422-023-00897-x. （第一作者兼共同通訊作者）
(3) Yingchao Shi*, Le Sun*, Mengdi Wang*, Jianwei Liu*, Suijuan Zhong, Rui Li, Peng Li, Lijie Guo, Ai Fang, Ruiguo Chen, Woo-Ping Ge, Qian Wu, Xiaoqun Wang. Vascularized human cortical organoids (vOrganoid) model cortical development in vivo. PLOS Biology, 2020, 18: e3000705. (被評(píng)為該雜志2020年度最受歡迎的 6 篇文章之一和慶祝創(chuàng)刊20周年專選文章)（第一作者）
(4) Yingchao Shi, Qian Wu, Xiaoqun Wang. Modeling brain development and diseases with human cerebral organoids. Current Opinion in Neurobiology, 2020, 66: 103-115.（第一作者）
(5) Yingchao Shi*, Shihua Li*, Qian Wu*, Le Sun, Junjing Zhang, Na Pan, Qihui Wang, Yuhai Bi, Jing An, Xuancheng Lu, George Fu Gao, Xiaoqun Wang. Vertical transmission of the Zika virus causes neurological disorders in mouse offspring. Scientific Reports, 2018, 8: 3541.（第一作者）
(6) Suijuan Zhong, Mengdi Wang, Luwei Huang, Youqiao Chen, Yuxin Ge, Jiyao Zhang, Yingchao Shi, Hao Dong, Xin Zhou, Bosong Wang, Tian Lu, Xiaoxi Jing, Yufeng Lu, Junjing Zhang, Xiaoqun Wang, Qian Wu. Single-cell epigenomics and spatiotemporal transcriptomics reveal human cerebellar development. Nature communication, 2023, 14:7613.
(7) Bo Zeng, Zeyuan Liu, Yufeng Lu, Suijuan Zhong, Shenyue Qin, Luwei Huang, Yang Zeng, Zixiao Li, Hao Dong, Yingchao Shi, Jialei Yang, Yalun Dai, Qiang Ma, Le Sun, Lihong Bian, Dan Han,Youqiao Chen, Xin Qiu, Wei Wang, Oscar Mar ??n, Qian Wu, Yongjun Wang, and Xiaoqun Wang. The single-cell and spatial transcriptional landscape of human gastrulation and early brain development. Cell Stem Cell, 2023, 30: 851–866.
(8) Congping Shang, Zhihui Liu, Zijun Chen, Yingchao Shi, Qian Wang, Su Liu, Dapeng Li, Peng Cao*. A parvalbumin-positive excitatory visual pathway to trigger fear responses in mice. Science, 2015, 348: 1472-1477.
(9) Zhihui Liu, Zijun Chen, Congping Shang, Fei Yan, Yingchao Shi, Jiajing Zhang, Baole Qu, Hailin Han, Yanying Wang, Dapeng Li, Thomas C. Sudhof, Peng Cao. IGF1-dependent synaptic plasticity of mitral cells in olfactory memory during social learning. Neuron, 2017, 95: 106-122.
(10) Xin Zhou, Yufeng Lu, Fangqi Zhao, Ji Dong, Wenji Ma, Suijuan Zhong, Mengdi Wang, Bosong Wang, Yuqing Zhao, Yingchao Shi, Qiang Ma, Tian Lu, Jun Zhang, Xiaoqun Wang, Qian Wu. Deciphering the spatial-temporal transcriptional landscape of human hypothalamus development. Cell Stem Cell, 2022, 29: 328-343.
(11) 王曉群, 吳倩, 時(shí)穎超, 郭麗潔. 一種紋狀體類器官的制備方法和應(yīng)用. 2020-1-20，中國(guó)，202010062009.0.
